Scientific Publications


The histone deacetylase inhibitor valproic acid sensitizes diffuse large B-cell lymphoma cell lines to CHOP-induced cell death.
Malin Ageberg, Karin Rydström, Thomas Relander and Kristina Drott
Am J Transl Res 5(2):170-83 (2013) PMID 23573362

Small airway relaxation 14A forgotten medical need.
Persson C.G.A. Pulmonary Pharmacol Theraupt, vol 21 (2008) 1-3.

Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchodilators.
Skogvall S., Berglund M., Dalence-Guzmán M.F., Svensson K., Jönsson P., Persson C.G.A., Sterner O. Pulmonary Pharmacol Theraupt, vol 20 (2007) 273-280.

Discovery of a potent bronchodilating capsazepinoid RESPIR 4-95.
Skogvall S., Dalence-Guzmán M.F., Berglund M., Svensson K., Mesic A., Jönsson P., Persson C.G.A., Sterner O. Pulmonary Pharmacol Theraupt, vol 21 (2008) 125-133.

SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure.
Dalence-Guzmán M. F., Berglund M., Skogvall S., Sterner O. Bioorganic & Medicinal Chemistry, vol 16 (2008) 2499-2512.

SAR studies of capsazepinoid bronchodilators. Part 2: Chlorination and catechol replacement in the A-ring
Berglund M., Dalence-Guzmán M.F., Skogvall S., Sterner O. Bioorganic & Medicinal Chemistry, vol 16 (2008), 2513-2528.

SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region)
Berglund M., Dalence-Guzmán M.F., Skogvall S., Sterner O. Bioorganic & Medicinal Chemistry, vol 16 (2008) 2529-2540.

Synthesis of novel tetrahydroisoquinoline bronchodilators
Dalence-Guzmán, M.F.; Toftered, J., Oltner, V.T.; Wensbo, D.; Johansson, M.H. Bioorganic & Medicinal Chemistry Letters, vol 20 (2010) 4999-5003.

Synthesis of novel tetrahydroisoquinoline bronchodilators
Dalence-Guzmán MF, Toftered J, Oltner VT, Wensbo D, Johansson MH
Bioorg Med Chem Lett. 2010 Sep 1;20(17):4999-5003

Capacity of capsazepinoids to relax human small airways and inhibit TLR3-induced TSLP and IFNb production in diseased bronchial epithelial cells.
Irma Mahmutovic Persson1, Martin Johansson2, Angelica Brandelius1, Jenny Calvén1, Leif Bjermer3, Yuliana Yudina1 and Lena Uller.
Int Immunopharmacol. 2012 Apr 26. (In press)